Mark Potter wrote these on the Yahoo Route 66 e-mail group a while back. These apply to both Route 66 and the interstates.
1. Travel in spoonfulls, 200-250 miles a day. (And, obviously, drive as much as you can on non-interstate roads. Don't allow the kids to watch DVDs the whole time. Let them look at the land as it goes by.)
2. Visit as many Route 66 attractions as possible (or any roadside attractions if on another road).
3. Buy gas in towns, preferably on 66. Gas is usually cheaper there than at off-ramps. Plus, you support Route 66 businesses.
4. Get your meals at mom-and-pop places. (Again, supporting 66 businesses, plus more of a chance to get regional food. Let's face it, you probably won't find horseshoe sandwiches on the menu at the local McDonald's.)
5. Stay at mom-and-pop motels which usually charge less and are comparable. (Just make sure it is a nice one. You can usually tell by looking at the grounds. If they are in good shape, the place is probably ok. A good idea also would be to ask to see the room. Plus, if the motel has chairs out on the porch, you can usually meet some interesting and friendly travelers.)
More to Come. --RoadDog